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Workup of Occult Malignancy

Inpatient Management Guide Work Up of Occult Malignancy FEATURES SUGGESTIVE OF MALIGNANCY Dermatomyositis/polymyositis, unexplained DVT/PE, Lambert-Eaton myasthenic syndrome, hyperviscosity syndrome, hypercalcemia, SIADH, unexplained weight loss When to Suspect Specific Malignancies Lung cancer: Risk factors: tobacco use, workplace exposures (eg. asbestos), age ≧40 Symptoms: chest pain, dyspnea, weight loss, hemoptysis, recurrent unexplained pneumonia (possible post-obstructive pneumonia) … Read more

VonWillebrand Hospital Care

Inpatient Management Guide Definition Congenital coagulation disorders: Inherited conditions that result in the absence or a reduction in particular coagulation factors. Disseminated Intravascular Coagulation (DIC): Acquired systemic consumptive coagulation disorder caused by excessive activation of the coagulation cascade that can result in diffuse microvascular thrombosis or bleeding depending upon whether thrombosis or fibrinolysis predominates. Vitamin … Read more

Vitamin K Deficiency

Inpatient Management Guide Definition Congenital coagulation disorders: Inherited conditions that result in the absence or a reduction in particular coagulation factors. Disseminated Intravascular Coagulation (DIC): Acquired systemic consumptive coagulation disorder caused by excessive activation of the coagulation cascade that can result in diffuse microvascular thrombosis or bleeding depending upon whether thrombosis or fibrinolysis predominates. Vitamin … Read more

Transfusion

Inpatient Management Guide Definition For standardized definitions and clinical criteria for transfusion reactions see: https://www.cdc.gov…  Febrile non-hemolytic transfusion reaction: Development of benign fever (>1 C change to >38C) or shaking chills during or within 4 hours after a transfusion. Self-limited with no major sequelae. This diagnosis can only be made by sending a post-reaction workup … Read more

Thyroid Disease

Inpatient Management Guide Definition Hypothyroidism: Primary hypothyroidism: failure of thyroid gland to secrete appropriate amount of thyroid hormone. ↑ TSH, ↓ fT4. Central hypothyroidism: rare (< 1% of hypothyroidism). failure of hypothalamus/pituitary gland to secrete appropriate amount of TRH/TSH, leading to decreased thyroid hormone secretion. Inappropriately normal or ↓ TSH, ↓ FT4. Subclinical hypothyroidism: mild … Read more

Thrombotic Thrombocytopenic Purpura

Inpatient Management Guide Definition Thrombocytopenia: defined as platelet counts below 150,000/µL, or 2 standard deviations below the lower limit of normal. Degrees of thrombocytopenia can be further subdivided into mild (100,000 to 150,000/μL), moderate (50,000 to 99,000/μL) and severe (< 50,000/μL). Microangiopathic Hemolytic Anemia (MAHA): non-immune mediated intravascular hemolytic anemia resulting from intravascular fragmentation of … Read more

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