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tPA for Acute Ischemic Stroke (2015)

  • Inclusion: Adult patients presenting to ED with acute ischemic stroke
  • Exclusion: Children < 18 years
  • Level A:
    • None.
  • Level B:
    • Offer IV tPA to acute ischemic stroke patients who meet NINDS inclusion/exclusion criteria and can be treated within 3 hours after symptom onset. Consider increased risk of symptomatic intracranial hemorrhage in decision to administer tPA. (May consider administration in carefully selected patients presenting within 3-4.5 hours of symptom onset.)

Clinical Policy: Use of intravenous tissue plasminogen activator for the management of acute ischemic stroke in the emergency department. Ann Emerg Med. 2015;66:322-333.PDF

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